Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
The Critics Choice Awards was held at the Barker Hangar in Santa Monica and saw Hollywood's A-listers get honoured at the first awards ceremony of the year.
Mouth-watering matches lined up as PSG to face Bayern and Barcelona in Champions League opening stage.
Arsenal maintained a searing pace at the top of the Premier League with a straightforward 2-0 win at Burnley, while Liverpool snapped a dreadful four-match losing run with a 2-0 victory over Aston Villa to climb provisionally to third.
Eberechi Eze scored a majestic hat-trick as Arsenal trounced north London rivals Tottenham Hotspur 4-1 to open up a commanding six-point lead.
Liverpool's Dominik Szoboszlai struck the first telling blow in the Premier League title race with a dazzling free kick late on giving his side a 1-0 victory over rivals Arsenal.
Erling Haaland took his league tally this season to 11 in eight games with both goals in City's 2-0 home win over Everton -- a result that temporarily put City above Arsenal on goals scored.
Images from Saturday's action in the English Premier League.
Manchester City's Erling Haaland became the fastest player to reach 100 Premier League goals to ignite their charge on Tuesday.
Chelsea climbed back into contention for next season's Champions League with a 1-0 home win over Everton in the Premier League on Saturday thanks to a fine first-half strike by Nicolas Jackson.
The EPL champions, old and new, produced a strictly mid-table performance in a goalless showdown.
Virgil van Dijk scored with a stunning late header in the second minute of stoppage time to give Liverpool a 3-2 victory over Atletico Madrid in their opening group stage match of the Champions League, at Anfield, on Wednesday.
Bayern Munich made it 16 wins from 16 games this season to underline their credentials as early Champions League favourites, beating holders Paris St Germain 2-1 away as Luis Diaz scored two goals and was shown a red card on Tuesday.
Didier Drogba scored twice on his return from a three-match European suspension as Chelsea drew 2-2 at Atletico Madrid to seal their place in the knock-out round of the Champions League on Tuesday. They were joined in the last 16 by Manchester United, Porto and Girondins Bordeaux, although four-time European champions Bayern Munich are on the brink of elimination after losing at home to the French champions.
In front of a tournament-high crowd of 81,188 at MetLife Stadium that included US President Donald Trump, Chelsea triumphed to bag the biggest club title.
Philippe Coutinho inspired Liverpool to a comfortable 3-1 home win over Everton in the 228th Merseyside derby on Saturday to move provisionally up to third in the Premier League.
Didier Drogba scored twice on his return from a three-match European suspension as Chelsea drew 2-2 at Atletico Madrid to seal their place in the knockout round of the Champions League on Tuesday. They were joined in the last 16 by Manchester United, Porto and Girondins Bordeaux, although four-time European champions Bayern Munich are on the brink of elimination after losing at home to the French champions.
Holders Chelsea and Premier League champions Manchester United were bundled out of the FA Cup quarter-finals. Chelsea lost 1-0 at Championship (second division) side Barnsley, while Portsmouth won 1-0 at Old Trafford.
Premier League Leeds United suffered the biggest upset of the FA Cup third round when they fell to a 3-0 defeat by fourth-tier Crawley Town on Sunday
Chelsea have the chance to avenge their shattering penalty shootout defeat to Manchester United in the 2008 final after being drawn to play them in the quarter-finals of the Champions League on Friday.
The prospect of the first repeat FA Cup final for 123 years increased on Monday when holders Chelsea and last year's beaten finalists Manchester United were kept apart in the quarter-final draw.
Manchester United languish 14th in the standings on 19 points, their worst placing to end a calendar year since they were 15th in 1989.
Mohamed Salah had already clinched the Premier League Player of the Season award, the Golden Boot for most goals scored and the Playmaker award for most assists, making him the first player to win all three awards in the same season.
IMAGES from the Premier League matches played on Wednesday.
Paris St Germain's Spanish midfielder Fabian Ruiz scored twice in a devastating first-half display as the French champions demolished Real Madrid 4-0 on Wednesday to book their place in the Club World Cup final against Chelsea.
Substitute Jorgen Strand Larsen scored twice in two minutes as Wolverhampton Wanderers beat fellow Premier League strugglers West Ham United 3-2 to reach the third round of the League Cup on Tuesday.
The two clubs were kept apart in the draw for the semi-finals for the FA Cup.
Man United boss Amorim says he has no plans to quit
A summary of Saturday's action in the English Premier League.
A number of Manchester United players are "not good enough" while some others are being "overpaid", the club's co-owner Jim Ratcliffe said.
A wake is expected to take place at a chapel in Gondomar from 4 PM (1500 GMT) and a funeral on Saturday at a church nearby at 10 AM local time, Gondomar's mayor's office said.
Manchester City clinched a 1-0 victory at Tottenham Hotspur, while Chelsea were held to a 0-0 draw at home by Aston Villa.
IMAGES from the Premier League matches played across England, on Sunday.
IMAGES from the English Premier League matches played on Wednesday.
Liverpool strolled to a 2-0 victory over Brentford, while Newcastle drew 1-1 at Bournemouth.
Wolves, who are unbeaten at home in the league since September, moved up to 11th with 22 points
Man Utd sign Mount from Chelsea on five-year deal
The win leaves United in 15th place in the Europa League standings on six points from four games.
A summary of Saturday's action in the FA Cup third round.